Thermo Fisher Scientific AVEN Polyclonal Antibody
AVEN 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 반응성. 액상 형태, 항원 친화 크로마토그래피로 정제. 세포자멸사 연구 및 백혈병 예후 인자 연구에 적합.
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Thermo Fisher Scientific AVEN Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human Aven |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152149 |
Product Specific Information
- Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.
- A suggested positive control is Raji cell lysate.
- PA5-20288 can be used with blocking peptide PEP-0406.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer.
Aven is a protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL and Apaf-1, interfering with Apaf-1 self-association and caspase activation.
Higher levels of Aven mRNA are observed in patients with acute leukemia compared to controls, suggesting Aven may serve as a prognostic indicator in leukemia research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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