Thermo Fisher Scientific TCR gamma/delta Monoclonal Antibody (B1.1), FITC, eBioscience
인간 γδ TCR 복합체를 인식하는 B1.1 단클론 항체로, FITC 형광 표지되어 유세포분석에 적합합니다. 정상 인간 말초혈액세포에서 검증되었으며, 488 nm 레이저에서 여기됩니다. 4°C 암소 보관, 동결 금지.
- 카탈로그번호
- 11-9959-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TCR gamma/delta Monoclonal Antibody (B1.1), FITC, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (4 µg)/test | View 14 publications |
| Functional Assay (Functional) | - | View 1 publication |
| In vitro Assay (IV) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B1.1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10669048 |
Additional Formats
Product Specific Information
Description:
The B1.1 monoclonal antibody reacts with the human gamma delta TCR complex. The gamma delta TCR is expressed by a small subset of T cells in the thymus, peripheral lymphoid tissues, intestinal epithelium, and epidermis. The exact specificity, ligand, and function of gamma delta TCR-bearing T cells are not yet fully understood. It is suggested that these cells recognize bacterial ligands and some tumor cells in the context of MHC class I-like gene products and play a role in immune regulation and bacterial infection response. This monoclonal antibody can be used as a phenotypic marker for gamma delta TCR-expressing T cells.
Applications Reported:
The B1.1 antibody has been reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended usage: 5 µL (4 µg) per test (100 µL final volume). Cell count: 10⁵–10⁸ cells/test (empirically determined).
Excitation / Emission: 488 nm / 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. TCRs discriminate foreign from self-peptides presented by MHC class II molecules, essential for adaptive immune response. Recognition of self-peptides has been linked to autoimmune diseases, while mutant self-peptides are associated with tumors. Engagement of TCRs by bacterial superantigens can lead to toxic shock syndrome. Autoantibodies to V beta segments of TCRs have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), potentially modulating inflammatory responses.
Most human T cells express TCR alpha-beta and either CD4 or CD8 (single positive). A small subset lacks both (double negative). Increased alpha-beta DN T cells are found in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily epithelial, showing less TCR diversity and distinct antigen recognition, with subsets exhibiting antitumor and immunoregulatory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.