Thermo Fisher Scientific CHEK2 Monoclonal Antibody (OTI2H5), TrueMAB
CHEK2 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot, IHC, Flow cytometry, IP 등에 사용 가능. 인간 및 개 반응성. 고순도 친화 크로마토그래피 정제. 액상 형태로 안정적인 저장 및 운송 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2 µg/500 µL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H5 |
| Immunogen | Full-length human recombinant protein of human CHEK2 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.18 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are associated with various cancers. CHK2 is activated by DNA damage and phosphorylates several modulators of cell cycle control, including tumor suppressor proteins such as BRCA1. It plays a key role in DNA repair and cell survival mechanisms. Mutations in the CHK2 gene are linked to Li-Fraumeni syndrome and may predispose individuals to sarcomas, breast cancer, and brain tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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