Thermo Fisher Scientific TPSG1 Monoclonal Antibody (OTI1E11), TrueMAB
TPSG1 단백질을 인식하는 Mouse monoclonal antibody (clone OTI1E11). Western blot과 Flow cytometry에 적합하며, 1 mg/mL 농도의 액상 형태로 제공. Human TPSG1에 특이적이며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–283 of human TPSG1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans. Tryptases belong to the trypsin-like serine protease family (peptidase family S1) and are enzymatically active only as heparin-stabilized tetramers, resistant to endogenous proteinase inhibitors.
Several tryptase genes are clustered on chromosome 16p13.3, with four functional genes identified: αI, βI, βII, and γI, each with known allelic variants. Beta tryptases are mainly expressed in mast cells, while alpha tryptases predominate in basophils. TPSG1 differs from other tryptase genes by having a C-terminal hydrophobic domain that may act as a membrane anchor. Tryptases are implicated as mediators in asthma and other allergic or inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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