Thermo Fisher Scientific CD106 (VCAM-1) Monoclonal Antibody (429), Functional Grade, eBioscience
마우스 CD106(VCAM-1)을 인식하는 단클론 항체로, 유동세포분석 및 기능적 차단 실험에 적합. 1 mg/mL 액상 형태로 제공되며, 4°C에서 보관. 높은 순도(>90%)와 낮은 엔도톡신 수준(<0.001 ng/µg)을 보장. 연구용으로만 사용 가능.
- 카탈로그번호
- 16-1061-xxx (5개 옵션)
- 판매단위
- pk
카탈로그
5개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD106 (VCAM-1) Monoclonal Antibody (429), Functional Grade, eBioscience
Thermo Fisher Scientific CD106 (VCAM-1) Monoclonal Antibody (429), Functional Grade, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | 9 publications |
| Neutralization (Neu) | Assay-Dependent | 1 publication |
| Functional Assay (Functional) | Assay-Dependent | - |
| Inhibition Assays (IA) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Functional Grade, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 429 |
| Conjugate | Functional Grade |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2865831 |
Available Formats
- Unconjugated
- APC
- Biotin
- eFluor 450
- eFluor 660
- FITC
- PE
- PE-Cyanine7
- Custom conjugation available upon request
Product Specific Information
The 429 monoclonal antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin α4β1 (VLA-4, CD49d/CD29) and integrin α4β7 (LPAM-1), which are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests its role in inflammatory responses.
Applications Reported:
- Flow cytometric analysis
- Blocking of CD106 in functional studies
Applications Tested:
Tested by flow cytometric analysis of mouse bone marrow cells. Recommended use ≤0.25 µg per test (100 µL final volume). Optimal antibody titration is advised for best assay performance.
Storage and Handling:
- Use in sterile environment
- 0.2 µm post-manufacturing filtered
Purity: >90% (SDS-PAGE)
Endotoxin Level: <0.001 ng/µg antibody (LAL assay)
Aggregation: <10% (HPLC)
Target Information
VCAM-1 is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. It regulates leukocyte migration and adhesion, and may play a role in inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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