Thermo Fisher Scientific CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GR-20), Functional Grade, eBioscience

Applications and Tested Dilution

Product Specifications

Product Specific Information

The monoclonal antibody GR-20 recognizes mouse CD119 (IFN gamma receptor 1).
CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor complex.
The ligand IFN gamma binds to the IFN gamma receptor 1 subunit, while signal transduction occurs via the IFN gamma receptor 2 subunit.
This receptor is involved in host defense and is broadly expressed in B cells, NK cells, macrophages, dendritic cells, and other non-hematopoietic cell types.
The GR-20 antibody has been reported to block IFN gamma binding to CD119.

Applications Reported:

• Flow cytometric analysis
• Functional assays (blocking cytokine binding to the receptor)

Storage and Handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: >90%, determined by SDS-PAGE.
Endotoxin Level: <0.001 ng/µg antibody, determined by LAL assay.
Aggregation: <10%, determined by HPLC.

Target Information

The IFNGR1 gene encodes the ligand-binding chain (alpha) of the gamma interferon receptor.
The human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2.
Genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection.
Defects in IFNGR1 can cause mendelian susceptibility to mycobacterial disease (familial disseminated atypical mycobacterial infection).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.