Thermo Fisher Scientific ATXN10 Polyclonal Antibody
ATXN10 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간 시료 반응성이 높으며, 항원 친화 크로마토그래피로 정제됨. 연구용으로 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific ATXN10 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATXN10. Recombinant protein control fragment (Product #RP-101275) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638392 |
Product Specific Information
Immunogen sequence:
KHPESEWPFL IITDLFLKSP ELVQAMFPKL NNQERVTLLD LMIAKITSDE PLTKDDIPVF LRHAELIAST F
Highest antigen sequence identity to the following orthologs:
- Mouse: 72%
- Rat: 82%
Target Information
The autosomal dominant cerebellar ataxias (ADCAs) are a clinically and genetically heterogeneous group of disorders characterized by ataxia, dysarthria, dysmetria, and intention tremor. All ADCAs involve some degree of cerebellar dysfunction and varying degrees of signs from other components of the nervous system. A commonly accepted clinical classification (Harding, 1993) divides ADCAs into three different groups based on the presence or absence of associated symptoms such as brainstem signs or retinopathy.
- ADCA I: presence of pyramidal and extrapyramidal symptoms and ophthalmoplegia
- ADCA II: presence of retinopathy
- ADCA III: absence of associated signs
Genetic linkage and molecular analyses revealed that ADCAs are genetically heterogeneous even within the various subtypes.
Additional Information
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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