Thermo Fisher Scientific NLRP3 Recombinant Rabbit Monoclonal Antibody (23H1L66)
Human NLRP3 단백질(aa3-112)에 특이적인 재조합 Rabbit Monoclonal 항체. Western blot에 최적화되어 있으며, Human에 반응하고 Mouse, Rat, Bovine에서도 예측 반응. Protein A 정제, 0.5 mg/mL 농도, PBS buffer에 sodium azide 포함.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23H1L66 |
| Immunogen | Protein corresponding to human NLRP3 (aa3–aa112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2895876 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
The NLRP3 gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif.
This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, a component of the NALP3 inflammasome complex.
The complex acts as an upstream activator of NF-kappaB signaling and plays roles in inflammation, immune response, and apoptosis.
Mutations in NLRP3 are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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