Thermo Fisher Scientific NLRP3 Recombinant Rabbit Monoclonal Antibody (23H1L66)

Applications

Western Blot (WB)

• Tested Dilution: 1:1000

Product Specifications

Product Specific Information

This antibody is predicted to react with Mouse, Rat, and Bovine.

Target Information

The NLRP3 gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif.
This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, a component of the NALP3 inflammasome complex.
The complex acts as an upstream activator of NF-kappaB signaling and plays roles in inflammation, immune response, and apoptosis.
Mutations in NLRP3 are associated with familial cold autoinflammatory syndrome and neonatal-onset multisystem inflammatory disease.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.