Thermo Fisher Scientific beta-2 Microglobulin Monoclonal Antibody (YTH470.5), Biotin
인간 Beta-2 Microglobulin을 인식하는 Rat monoclonal antibody (Clone YTH470.5). Western blot 및 Flow cytometry에 사용 가능. Biotin으로 표지되어 있으며 Protein G로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | 0.5 µg/1×10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YTH470.5 |
| Immunogen | Rat monoclonal antibody raised against human lymphocytes |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539074 |
Additional Formats
Product Specific Information
MA5-17684 targets Beta 2-microglobulin in FACS and WB applications and shows reactivity with human samples.
The MA5-17684 immunogen is a rat monoclonal antibody raised against human lymphocytes.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
It is also found in free form in plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation.
Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15. Mutations in this gene have been linked to hypercatabolic hypoproteinemia.
Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients and serve as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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