Thermo Fisher Scientific beta-2 Microglobulin Monoclonal Antibody (YTH470.5), FITC
Human beta-2 Microglobulin을 인식하는 Rat monoclonal antibody (Clone YTH470.5)로 FITC 형광 표지. FACS 및 Western blot에 적합하며, 높은 특이성과 안정성 제공. 단기 4°C, 장기 -20°C 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- 0.5 µg/1x10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YTH470.5 |
| Immunogen | Rat monoclonal antibody raised against human lymphocytes |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw). Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539075 |
Additional Formats
- APC (MA5-17683)
- Biotin (MA5-17684)
- PE (MA5-17686)
- Custom conjugation available upon request
Product Specific Information
MA5-17685 targets Beta-2-microglobulin in FACS and WB applications and shows reactivity with human samples.
The immunogen is a rat monoclonal antibody raised against human lymphocytes.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the MHC class I complex. It is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but absent on erythrocytes.
B2M is also found free in plasma and shares sequence homology with immunoglobulin constant regions, forming a beta-pleated sheet structure.
It is involved in antigen processing, presentation, and TCR signaling, particularly in naive CD8+ cells.
Encoded by the B2M gene on chromosome 15, mutations can cause hypercatabolic hypoproteinemia.
Beta-2-microglobulin levels are used to evaluate renal function and as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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