Thermo Fisher Scientific NMDAR2B (GluN2B) (extracellular) Polyclonal Antibody, Atto 594

Applications

Tested Application and Dilution

• Immunohistochemistry (Frozen) (IHC (F)): 1:50

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL of double distilled water (DDW), depending on sample size.
• The antibody ships as a lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and store at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

NMDAR2B is a subunit of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, a mechanism underlying memory and learning processes.
NMDAR2B plays a role in neuronal development and is implicated in several central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of NR2B enhances learning and memory, while reduced NR2B expression is observed in aged or memory-impaired animals. Phosphorylation of Tyr1472 on NR2B may increase synaptic expression and plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits. Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant intellectual disability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.