Thermo Fisher Scientific APEX2 Polyclonal Antibody
Human APEX2 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, Protein G로 정제된 액상 포맷. PBS/BSA 버퍼에 보존되고, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Rabbits were immunized with EELRALDSEGRALLTQHKI (aa122–140) and GQAKTSEAKDEKELRTSF (aa438–455) peptides of human APEX2. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2058091 |
Product Specific Information
PA1-29809 detects APEX2 from human samples.
Target Information
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, DNA damaging agents, or DNA glycosylases that remove abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication, so the cell has systems to identify and repair such sites.
Class II AP endonucleases cleave the phosphodiester backbone 5′ to the AP site. This gene encodes a protein with weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus, but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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