Thermo Fisher Scientific MBD1 Polyclonal Antibody
인간 MBD1 단백질을 인식하는 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, PBS 완충액에 0.02% sodium azide를 포함. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides RQVGPQSGEVKEAPR and PEEDKEENKDDSASK, corresponding to amino acids 98–113 and 342–356 of Human MBD1, respectively. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1958323 |
Product Specific Information
PA1-29797 detects MBD1 from human samples.
Target Information
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It functions as a transcriptional repressor that binds CpG islands in methylated promoters. Binding is abolished by the presence of 7-mG, which is produced by DNA damage from methylmethanesulfonate (MMS). MBD1 mediates gene silencing by recruiting AFT7IP and histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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