Thermo Fisher Scientific KCNH2 Polyclonal Antibody
HERG 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, IP에 사용 가능. 사람 시료에 반응하며 비결합형 액상 형태. -20°C 보관, 0.05% sodium azide 함유. 연구용으로만 사용.
- 카탈로그번호
- PA3860
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:20,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:3,000 | - |
| Immunoprecipitation (IP) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein of HERG encoding 181 amino acid residues from the C-terminus |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2132141 |
Product Specific Information
PA3-860 detects HERG in human samples.
It has been successfully used in Western blot, immunofluorescence, and immunoprecipitation procedures.
By Western blot, this antibody detects the ~135 kDa and ~155 kDa forms of HERG.
The immunogen corresponds to a cDNA fragment of HERG encoding 181 amino acid residues from the C-terminus.
Target Information
The human ether-a-go-go related gene (HERG, KCNH2) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr.
There are two N-terminal splice variants: full-length isoform 1 alpha and shorter isoform 1 beta.
Isoform 1 beta lacks the PAS motif and deactivates faster than isoform 1 alpha.
Residues within the C-terminus are important for channel expression and voltage-dependent activation.
HERG is predominantly expressed in the heart, especially in ventricles.
Mutations in HERG can cause long QT syndrome type 2 and short QT syndrome type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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