Thermo Fisher Scientific Cathepsin A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 210-450 of human CTSA (NP_001121167.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cathepsin A,uniProtId:P10619-1,ncbiNodeId:9606,antigenRange:210-450,antigenLength:480,antigenImageFileName:PA5-120921_Cathepsin_A_P10619-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120921_Cathepsin_A_P10619-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.85 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914493

Product Specific Information

Positive test controls include: SH-SY5Y, Mouse brain, Rat kidney. The target is usually found in the following locations: Lysosome.

Immunogen sequence: SYEQNDNSLV YFAYYHGLLG NRLWSSLQTH CCSQNKCNFY DNKDLECVTN LQEVARIVGN SGLNIYNLYA PCAGGVPSHF RYEKDTVVVQ DLGNIFTRLP LKRMWHQALL RSGDKVRMDP PCTNTTAAST YLNNPYVRKA LNIPEQLPQW DMCNFLVNLQ YRRLYRSMNS QYLKLLSSQK YQILLYNGDV DMACNFMGDE WFVDSLNQKM EVQRRPWLVK YGDSGEQIAG FVKEFSHIAF L

Target Information

The cathepsin family of proteolytic enzymes include several diverse classes of proteases. Cathepsins B, L, H, K, S and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyle protease class. The serine protease class includes cathepsin G. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation. Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with b-galactosidase (b-gal) and a-neuraminidase (Neu1). Cathepsin A functions to protect b-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in b-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause glactosialidosis, a lysosomal storage disorder resulting from the b-gal and Neu1 deficiencies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.