Thermo Fisher Scientific Cathepsin A Polyclonal Antibody
Thermo Fisher Scientific의 Cathepsin A Polyclonal Antibody는 인간, 마우스, 랫트 시료에 반응하며 WB와 ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 높은 특이성과 안정성을 제공합니다. 연구용으로 사용되며, 라이소좀 내 Cathepsin A 단백질 검출에 유용합니다.
- 카탈로그번호
- PA5120921
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 210–450 of human CTSA (NP_001121167.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914493 |
Product Specific Information
Positive test controls include: SH-SY5Y, Mouse brain, Rat kidney.
The target is usually located in the lysosome.
Immunogen sequence:
SYEQNDNSLV YFAYYHGLLG NRLWSSLQTH CCSQNKCNFY DNKDLECVTN LQEVARIVGN SGLNIYNLYA PCAGGVPSHF RYEKDTVVVQ DLGNIFTRLP LKRMWHQALL RSGDKVRMDP PCTNTTAAST YLNNPYVRKA LNIPEQLPQW DMCNFLVNLQ YRRLYRSMNS QYLKLLSSQK YQILLYNGDV DMACNFMGDE WFVDSLNQKM EVQRRPWLVK YGDSGEQIAG FVKEFSHIAF L
Target Information
The cathepsin family of proteolytic enzymes includes several diverse classes of proteases:
- Cysteine proteases: Cathepsins B, L, H, K, S, O
- Aspartyle proteases: Cathepsins D, E
- Serine protease: Cathepsin G
Cathepsins participate in cellular metabolism, peptide biosynthesis, and protein degradation.
Cathepsin A, a serine carboxypeptidase, forms a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1).
It protects β-gal and Neu1 from intralysosomal proteolysis.
Deficiencies in Cathepsin A lead to deficiencies in β-gal and Neu1, causing galactosialidosis, a lysosomal storage disorder.
The human Cathepsin A gene maps to chromosome 20q13.12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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