Thermo Fisher Scientific MAGEC2 Polyclonal Antibody

Thermo Fisher Scientific MAGEC2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total MAGEC2.

Target Information

MAGE-C2/C3 (Melanoma-associated antigen C2, Hepatocellular carcinoma-associated antigen 587) is a 373 amino acid protein encoded by the human gene MAGEC2.
Genes of the MAGE family direct the expression of tumor antigens recognized on human melanomas by autologous cytolytic T lymphocytes.
Among tumor tissues, MAGE-C2/C3 is frequently expressed in seminomas, melanomas, and bladder transitional cell carcinomas. It is also expressed in a significant fraction of head and neck carcinomas, breast carcinomas, nonsmall-cell lung carcinomas, and sarcomas.
In hepatocellular carcinoma, there is an inverse correlation between tumor differentiation and protein expression — the lower the differentiation, the higher the percentage of expression.
MAGE-C2/C3 is not expressed in normal tissues except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. It is strongly expressed in spermatogonia and primary spermatocytes; however, at later stages of maturation, expression gradually decreases to become undetectable in mature spermatids.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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