Thermo Fisher Scientific LOK Polyclonal Antibody
Thermo Fisher Scientific의 LOK Polyclonal Antibody는 인간 STK10 단백질을 인식하는 토끼 IgG 항체로, WB, IHC(P), ICC/IF에 적합합니다. 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STK10 (Accession O94804), corresponding to amino acid residues S495–S545 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851457 |
Product Specific Information
Antibody detects endogenous levels of total STK10.
Target Information
Ubiquitin exists either covalently attached to another protein or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of ubiquitin (polyubiquitin chains), or a linear polymer linked via the initiator Met of ubiquitin (linear polyubiquitin chains).
Polyubiquitin chains have different functions depending on the Lys residue linkage:
- Lys-6-linked: DNA repair
- Lys-11-linked: ERAD and cell-cycle regulation
- Lys-29-linked: lysosomal degradation
- Lys-33-linked: kinase modification
- Lys-48-linked: proteasomal degradation
- Lys-63-linked: endocytosis, DNA-damage response, NF-kappa-B signaling
Linear polymer chains formed via Met linkage are involved in cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, occasionally to Cys or Ser residues. Free polyubiquitin also plays roles in activation of protein kinases and signaling.
60S ribosomal protein L40 is a component of the 60S ribosomal subunit, essential for translation of specific cellular transcripts, particularly cap-dependent translation of vesicular stomatitis virus mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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