Thermo Fisher Scientific Angiogenin Monoclonal Antibody (14017.7)
인간 Angiogenin 단백질을 인식하는 마우스 단클론 항체. Western blot, IHC, ELISA 등 다양한 응용에 적합. 단백질 G 정제 및 PBS buffer 보존. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | – |
| Immunohistochemistry (IHC) | 1:1,000 | – |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| ELISA | 2–8 µg/mL | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 14017.7 |
| Immunogen | Recombinant, full length, human angiogenin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2227146 |
Product Specific Information
- Recommended positive control: mouse liver
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
Target Information
Angiogenin (ANG or ANG I) is critical for neovascularization and new blood vessel formation. It is similar to pancreatic ribonuclease A and acts as a tRNA-specific ribonuclease that inhibits protein synthesis by hydrolyzing cellular tRNAs. ANG interacts with endothelial cell-surface actin, leading to cytoskeletal changes. It is implicated in solid tumor development, and its antagonists can inhibit tumor growth. Mutations in ANG are associated with amyotrophic lateral sclerosis type 9 (ALS9), linking ANG to both ALS and Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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