Thermo Fisher Scientific SOAT1 Polyclonal Antibody
SOAT1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. Protein A 정제, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human SOAT1 (amino acids 51–150) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SOAT1 (sterol O-acyltransferase-1), also known as ACAT1, is a homotetrameric enzyme that catalyzes the formation of cholesterol esters from cholesterol and long-chain fatty acyl-CoA. The human SOAT1 gene maps to chromosome 1 and encodes a protein localized to the endoplasmic reticulum (ER) in various tissues, including liver, kidney, adrenal glands, and macrophages.
SOAT1 plays a critical role in cellular cholesterol homeostasis, foam cell formation, and atherosclerosis progression. Inhibitors of SOAT1 have been studied for potential therapeutic use in atherosclerosis.
SOAT2 (sterol O-acyltransferase-2), also known as ACAT2, participates in lipoprotein assembly and cholesterol esterification, primarily in intestinal cells. Deficiency in SOAT2 has been associated with severe mental retardation and hypotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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