Thermo Fisher Scientific VPS72 Polyclonal Antibody
VPS72 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 검증됨. 인간 및 마우스 시료에 반응하며, 고순도(>95%)로 정제됨. 액상 형태로 제공되며, 단기 4°C 보관 및 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 116–168 of human VPS72 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553472 |
Product Specific Information
- Detects endogenous VPS72 protein at approximately 41 kDa.
- Purity is greater than 95% by SDS-PAGE.
Target Information
Vacuolar protein sorting-associated protein 72 homolog (VPS72), also known as VPS72 or Transcription factor-like 1, is a 364 amino acid subunit of the TRRAP/TIP60 HAT complex.
VPS72 is also part of a complex containing SNF2-related helicase SRCAP (SWI2/SNF2-related CBP activator protein), which is similar to the S. cerevisiae SWR1 chromatin remodeling complex.
These associations suggest VPS72 plays multiple roles in chromatin modification and remodeling. VPS72 localizes to the nucleus and is phosphorylated upon DNA damage, most likely by ATM or ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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