Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI3B7)
인간 CD137(TNFRSF9) 인식 단일클론 항체로 Flow Cytometry에 적합. 마우스 IgG1 형식, 무보존제, 동결건조 형태. 활성화 T세포 표지 및 면역조절 연구용으로 사용 가능.
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- CF813225
- 판매단위
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B7 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
CD137 (TNFRSF9, 4-1BB) is an inducible costimulatory molecule mainly expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling promotes survival and clonal expansion of activated and memory CD8+ T cells, while modulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release affecting peripheral monocyte survival. Soluble CD137 may act as a negative regulator in certain immune responses.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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