Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI3B8)

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

CD137 (TNFRSF9, 4-1BB) is an inducible costimulatory molecule primarily expressed on activated T cells. Its ligand, 4-1BBL, is found on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling supports the survival and clonal expansion of activated and memory CD8+ T cells while modulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble CD137 may serve as a negative regulatory mechanism in immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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