Thermo Fisher Scientific Phospho-SPHK2 (Thr578) Polyclonal Antibody
Phospho-SPHK2 (Thr578) 폴리클로날 항체로 인간, 마우스, 랫트 반응성. Western blot에 1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체이며, 세포 내 신호전달 및 S1P 관련 연구에 적합. -20°C 보관.
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Thermo Fisher Scientific Phospho-SPHK2 (Thr578) Polyclonal Antibody
Applications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Phospho-SK2 (Thr-578) synthetic peptide (coupled to KLH) corresponding to amino acid residues surrounding Thr-578 in human SK2. This peptide sequence is highly conserved in rat and mouse SK2 proteins, and is not well conserved in SK1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2943002 |
Product Specific Information
This antibody detects 70 kDa proteins corresponding to the molecular mass of SK2 on SDS-PAGE immunoblots of human recombinant SK2 and endogenous SK2 in human HeLa cells treated with calyculin A. This reactivity is not observed after lambda phosphatase treatment.
Target Information
SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P).
S1P signals through G-protein coupled receptors and controls diverse cellular processes. Inhibitors of SPHKs are viewed as potential therapeutics for cancer treatment.
SPHK2 plays key roles in cell differentiation, calcium mobilization, and apoptosis.
S1P receptors (EDG family) couple to multiple G proteins (e.g., S1P1 to Gi; S1P2 and S1P3 to Gq, G13, Gi) and regulate cell motility, survival, migration, and interaction.
S1P also contributes to cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, neuronal and bone cell regulation.
S1P levels are controlled by Sphk1 and Sphk2 activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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