Thermo Fisher Scientific PKM2 Monoclonal Antibody (OTI1E7), TrueMAB
PKM2 단백질을 표적으로 하는 마우스 단클론 항체로, IHC(P) 실험에 적합합니다. 합성 펩타이드 면역원으로 제작되었으며, 동결건조 형태로 제공됩니다. 고순도의 친화 크로마토그래피 정제 제품으로, 연구용으로만 사용 가능합니다.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E7 |
| Immunogen | Synthetic peptide sequence corresponding to the region encoded by PKM gene M2 isoform |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Synthetic peptide sequence: LRRLAPITSDPTEATAVGAV
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PKM2 (Pyruvate Kinase M2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and ATP.
It interacts with thyroid hormone, potentially mediating cellular metabolic effects induced by thyroid hormones.
PKM2 also binds to Opa protein, a bacterial outer membrane protein involved in gonococcal adherence and invasion of human cells, suggesting a role in bacterial pathogenesis.
Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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