Thermo Fisher Scientific Pan-CDH Monoclonal Antibody (OTI1A7), TrueMAB

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Pan Cadherin, including CDH1, CDH2, CDH3, and CDH4, are transmembrane molecules mediating calcium-dependent intercellular adhesion.
Cadherins regulate morphogenetic movements during development and control cell surface adhesion through homotypic interactions.
N-cadherin function depends on its association with the actin cytoskeleton via interactions between its C-terminal region and cytoplasmic catenin proteins.
This association is regulated by phosphorylation and dephosphorylation of beta-catenin.
The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein with five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail.
It functions during gastrulation and is essential for establishing left-right asymmetry.
At certain CNS synapses, presynaptic to postsynaptic adhesion is mediated in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.