Thermo Fisher Scientific Human TAK1 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the amino terminus of human TAK1 (NT).
PEP-0201 can be used as a blocking peptide with polyclonal antibody PA5-20083.

Target Information

TAK1 (also known as MAP3K7), a member of the serine/threonine kinase family, is a multifunctional protein involved in various signaling pathways. Initially identified as a TGF-β-activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to regulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, responding to thyroid hormone, osmotic stress, endothelin, and ephrine. Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin β1, and β5, contributing to wound healing. TAK1 is crucial for IKK activation in pathways involving IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. This activation requires TAB2/3 and ubiquitination, leading to TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, followed by phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.