Thermo Fisher Scientific Human ECSIT Synthetic Peptide
인간 ECSIT 단백질의 카복시 말단 14개 아미노산 서열 기반 합성 펩타이드. NF-κB 및 TLR 신호전달 연구용 차단 펩타이드로 사용 가능. 200 µg/mL 농도의 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA 포함. 연구용 전용 시약.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human ECSIT.
PEP-0200 can be used as a blocking peptide with polyclonal antibody PA5-20082.
Target Information
Activation of NF-kappa-B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88 to kinases (e.g., IRAK) and intermediates such as TNF receptor associated factor (TRAF)-6.
ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TRAF6 in the TLR pathway.
ECSIT is also required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, suggesting possible cross-talk between the TLR/IL-1B and Bmp signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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