Thermo Fisher Scientific Human TAB1 Synthetic Peptide
인간 TAB1 중심부 13개 아미노산 서열 기반 합성 펩타이드로, PA5-20084 항체의 블로킹 펩타이드로 사용 가능. TGF-β 및 MAPK 경로 연구용으로 적합하며, 고순도 정제된 액상 형태로 제공. 연구용 한정 제품.
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Thermo Fisher Scientific Human TAB1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 13 amino acids near the center of human TAB1.
PEP-0202 can be used as a blocking peptide with polyclonal antibody PA5-20084.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, mediating various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase.
The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal portion acts as a dominant-negative inhibitor of TGF beta, suggesting TAB1 functions as a mediator between TGF beta receptors and TAK1.
TAB1 also interacts with and activates MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 biological responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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