Thermo Fisher Scientific Human TAB1 Synthetic Peptide

Thermo Fisher Scientific Human TAB1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the center of human TAB1.
PEP-0202 can be used as a blocking peptide with polyclonal antibody PA5-20084.

Target Information

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, mediating various intracellular signaling pathways such as those induced by TGF beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase.
The C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while the N-terminal portion acts as a dominant-negative inhibitor of TGF beta, suggesting TAB1 functions as a mediator between TGF beta receptors and TAK1.
TAB1 also interacts with and activates MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 biological responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.