Thermo Fisher Scientific KRT3/6A/75/76 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total K22O.

Target Information

The type II cytokeratins consist of basic or neutral proteins arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues.
KRT3 (Keratin 3) is specifically expressed in the corneal epithelium with family member KRT12, and mutations in these genes have been associated with Meesmann's Corneal Dystrophy.
Type II cytokeratins are clustered in a region of chromosome 12q12–q13. As many as six KRT6 genes have been identified; the multiplicity of genes is attributed to successive gene duplication events.
These genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, oral mucosa and esophagus, outer root sheath of hair follicles, and glandular epithelia.
This KRT6 gene encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita.
Peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens.
KRT75 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in epithelial cells.
This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.