Thermo Fisher Scientific Lamin B1 Recombinant Rabbit Monoclonal Antibody (10H34L18)
Lamin B1 단백질을 인식하는 재조합 토끼 단클론 항체로 Western blot, IHC, ICC, ChIP 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, 다양한 형광 표지 포맷으로도 제공됩니다. 연구용 전용 시약입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:50,000 | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–2.5 µg/mL | - |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | 1 publication |
| ChIP assay (ChIP) | 2 µg/10^6 cells | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10H34L18 |
| Immunogen | Peptides corresponding to human LAMIN B1 (aa62–aa79, aa450–aa467) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784553 |
Additional Formats
Product Specific Information
This antibody is predicted to react with Monkey, Sheep, Bovine, and Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, and individual clones are screened for optimal production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
Laminins are extracellular matrix glycoproteins and key components of basement membranes. They participate in various biological processes such as:
- Cell adhesion
- Differentiation
- Migration
- Signaling
- Neurite outgrowth
- Metastasis
Laminins consist of three non-identical chains (alpha, beta, and gamma; formerly A, B1, and B2), forming a cruciform structure.
Mutations in the LMNB1 gene can cause Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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