Thermo Fisher Scientific MSH6 Polyclonal Antibody
MSH6 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, IP 등 다양한 응용에 적합. 액상 형태로 제공되며 4°C 보관. FFPE 조직의 IHC에 citrate buffer(pH 6.0) 전처리 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:250–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:250–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1300 and the C-terminus (residue 1360) of human MutS homolog 6 (MSH6, UniProt ID: P52701-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The DNA mismatch repair MSH2/MSH6 heterodimer is responsible for the detection of DNA damage and may promote apoptosis in normal cells. This mechanism protects mammals from ultraviolet-induced malignant transformation, contributing to the prevention of skin cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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