Thermo Fisher Scientific NCOA2/SRC2 Polyclonal Antibody

Product Specifications

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2 or TIF2), aids in the function of nuclear hormone receptors.
Nuclear hormone receptors are conditional transcription factors that play important roles in cell growth, development, and homeostasis by controlling gene expression.

Members of the nuclear hormone receptor superfamily include five steroid receptors and class II nuclear receptors, characterized by three distinct domains:

• N-terminal transcriptional activation domain
• Central DNA-binding domain
• C-terminal hormone-binding domain

Before hormone binding, steroid receptors remain inactive in a complex with heat-shock protein-90 and other stress family proteins.
Hormone binding induces conformational changes, allowing receptors to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements, and modulate transcription.
After enhancer binding, transcription factors require coactivator proteins, such as SRC2, to stimulate transcription initiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.