Thermo Fisher Scientific Phospho-SHC (Tyr239, Tyr240) Polyclonal Antibody
인산화 SHC(Tyr239, Tyr240)를 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합. Human에 반응하며 Mouse, Rat 등에서도 예측 반응성 있음. 고농축 액상 형태로 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human SHC1 (phospho Tyr239/240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.83 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792962 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Rhesus Monkey (100%), Bovine (100%).
- Positive Control: HepG2 (starvation for 16 hr and 200 ng/ml EGF treatment for 30 min).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex.
Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts.
Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays.
In normal tissues, Skp2 is expressed in tonsil and placenta.
In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers.
Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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