Thermo Fisher Scientific ErbB4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Positive Control: Breast carcinoma or skeletal muscle.

Target Information

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing various cellular responses including mitogenesis and differentiation.
ErbB4 acts as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation.
It regulates key cellular processes such as metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, movement, apoptosis, and differentiation.

ErbB4 is predominantly expressed in several breast carcinoma cell lines and in normal skeletal muscle, heart, pituitary, brain, and cerebellum.
High mRNA levels are found in T47-D, MDA-MB-453, BT-474, and H3396 cell lines; intermediate levels in MCF-7, MDA-MB-330, and MDA-MB-361; and low or absent expression in MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3.
Elevated ErbB4 levels in certain tumor cell lines suggest a possible role in malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.