Thermo Fisher Scientific Phospho-S6 (Ser240, Ser244) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (100%), Dog (100%), Chicken (100%), Bovine (100%).
• Positive Control: C8D30, C2C12, 293T (starvation for 24 hr, and 20% FBS treatment for 30 min).
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.
This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit and belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different kinases.
Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens, while dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through selective translation of particular classes of mRNA.
As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.