Thermo Fisher Scientific EpCAM Polyclonal Antibody
EpCAM 단백질을 표적하는 토끼 다클론 항체로, Western blot, ELISA, Immunoprecipitation에 적합합니다. 인간 시료 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 -20°C 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific EpCAM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 215–265 of human Tumor-associated calcium signal transducer 1 protein (EpCAM, CD326, UniProt ID: P16422-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol and 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ep-CAM (epithelial adhesion molecule, ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a calcium-independent cell adhesion molecule influencing cell cycle, proliferation, and metabolism through induction of proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth. Overexpression correlates with increased epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for epithelial lineage tumors.
Ep-CAM is localized on the baso-lateral surface of most simple epithelia and many carcinoma types, and can distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
제품 이미지
(이미지 파일: TACSTD1-112AP_EpCAM_CD326_P16422-1_Rabbit.svg, TACSTD1-112AP_EpCAM_CD326_P16422-1_Rabbit_PDP.jpeg)
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