Thermo Fisher Scientific Cyclophilin B Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• TAB1002 detects Cyclophilin B in samples.
• TAB1002 has been successfully used in Western Blot applications.
• The immunogen is a KLH-conjugated peptide corresponding to human cyclophilin B.

Target Information

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents — cyclosporin A (CsA) or FK506. Proteins binding FK506 are termed FK506 Binding Proteins (FKBPs), and those binding cyclosporin A are called cyclophilins (CyPs). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase involved in T-cell activation, providing a mechanism of immunosuppression by CsA and FK506.

Immunophilins function as peptidyl-prolyl cis-trans-isomerases (PPIases), whose activity is inhibited by their respective immunosuppressant compounds. As PPIases, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the folding and rearrangement of proline-containing proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.