Thermo Fisher Scientific Bcl-10 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Bcl10 protein. Validated for Western blot at 1:500 dilution. Detects ~26 kDa Bcl10 band in transfected 293 cells. Suitable for apoptosis and NF-κB signaling research. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2063988 |
Product Specific Information
PA1-4129 detects Bcl10 in human samples.
It has been successfully used in Western blot procedures.
By Western blot, this antibody detects a ~26 kDa protein representing Bcl10 in transfected 293 cells.
The PA1-4129 immunogen is a synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein involved in the adaptive immune response.
It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-κB via NIK and IKK.
BCL-10 acts as an adapter protein between the upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex.
It is a substrate for MALT1.
Mutations in the gene can lead to Immunodeficiency 37 or mucosa-associated lymphoid type lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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