Thermo Fisher Scientific Bcl-10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BCL-10,uniProtId:O95999-1,ncbiNodeId:9606,antigenRange:220-233,antigenLength:233,antigenImageFileName:PA1-4129_BCL-10_O95999-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4129_BCL-10_O95999-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2063988

Product Specific Information

PA1-4129 detects Bcl10 in human samples.

PA1-4129 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~26 kDa protein representing Bcl10 in transfected 293 cells.

The PA1-4129 immunogen is a synthetic peptide corresponding to residues E(220) M F L P L R S R T V S R Q(233) C of Bcl10.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.