Thermo Fisher Scientific TRAF7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Immunoprecipitation (IP)

1:20-1:1,000

-

Product Specifications

Species Reactivity

Horse, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues 334-356 of human TRAF7. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TRAF7,uniProtId:Q6Q0C0-1,ncbiNodeId:9606,antigenRange:334-356,antigenLength:670,antigenImageFileName:PA1-41285_TRAF7_Q6Q0C0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-41285_TRAF7_Q6Q0C0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.0 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2303748

Product Specific Information

Suggested positive control: antigen standard for TRAF7 (transient overexpression lysate).

Target Information

TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.