Thermo Fisher Scientific Phospho-c-Kit (Tyr703) Recombinant Superclonal Antibody (22HCLC)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Rat, Mouse, Pig, Bovine, Rabbit, and Dog.

Recombinant rabbit Superclonal™ antibodies from Thermo Fisher Scientific combine the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
They recognize multiple epitope sites on the target, providing higher detection sensitivity for low-abundance proteins.
Each lot contains a known recombinant mixture of light and heavy chains, ensuring reproducible performance and eliminating biological variability.

Note: Formerly called “Recombinant polyclonal antibody,” this product is now branded as “Recombinant Superclonal™ antibody.” The physical product and performance remain unchanged.

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for mast cell growth factor (MGF, also known as stem cell factor, SCF).
It regulates growth and activation of various hematopoietic and non-hematopoietic cells. Mutations in KIT are linked to gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism.

Upon SCF binding, c-Kit dimerizes and autophosphorylates on tyrosine residues, including Tyr703, enabling Grb2 docking and Ras/ERK signaling activation.
SCF/c-Kit also activates PI3K, PLC-γ, and JAK/STAT pathways, essential for hematopoiesis, stem cell maintenance, and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.