Thermo Fisher Scientific FPR1 Polyclonal Antibody
FPR1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 시료에 반응합니다. 면역조직화학(IHC)용으로 최적화되어 있으며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 장기보관 시 -20°C에서 안정적으로 유지됩니다.
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Thermo Fisher Scientific FPR1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 5–10 µg/mL
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 3rd extracellular domain of human FPR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550916 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla (100%)
Orangutan (94%)
Gibbon (83%)
Target Information
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils, and monocytes.
It is a seven transmembrane pertussis toxin-sensitive GPCR that binds to formylated peptides generated by bacteria, resulting in leukocyte trafficking to sites of inflammation.
Ligand binding to FPR activates multiple effectors including phospholipase C, leading to calcium mobilization and PKC activation.
Other implications of FPR signaling include:
- Polarization of actin cytoskeleton
- Activation of various integrins
- Increased cell migration, phagocytosis, degranulation
- Release of reactive oxygen intermediates
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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