Thermo Fisher Scientific AMPK beta-1 Polyclonal Antibody
Rabbit polyclonal antibody targeting AMPK beta-1 subunit for IHC and ICC/IF applications. Reacts with human, mouse, and rat. High purity (>95%) and antigen affinity purified. Supplied in PBS with 50% glycerol; store at 4°C or -20°C.
- 카탈로그번호
- PA586450
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human AMPK beta-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803228 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
AMPK beta-1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. AMPK acts as an energy-sensing enzyme that monitors cellular energy status.
In response to metabolic stress, AMPK becomes activated and phosphorylates key enzymes such as acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), which regulate fatty acid and cholesterol biosynthesis.
The beta-1 subunit may positively regulate AMPK activity. Myristoylation and phosphorylation of this subunit influence enzyme activity and cellular localization. It may also function as an adaptor molecule mediating AMPK complex assembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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