Thermo Fisher Scientific ROBO3 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MTPPLQGPRA RFRKKPKALP YRRENSPGDL PPPPLPPPEE EASWALELRA AGSMSSLERE RSGERKAVQA VPLAAQRVLH PDEEAWLPYS RPSFLSRGQG TSTCSTAGSN SSRGSSSSRG SRGPGRSRSQ SRSQSQRPGQ KRREEPR

Target Information

This gene belongs to the Roundabout (ROBO) gene family, which regulates neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are part of the immunoglobulin transmembrane receptor superfamily. SLIT proteins (1–3) act as ligands for ROBO proteins, and SLIT/ROBO interactions influence processes such as myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, vasculogenesis, and neurogenesis.

ROBO3 features:

• Extracellular domain with five Ig-like loops and three fibronectin type III motifs
• Transmembrane segment
• Cytoplasmic tail with conserved signaling motifs CC0, CC2, and CC3 (lacking CC1)

Loss of ROBO3 function in mice causes failure of commissural axons to cross the midline in the spinal cord and hindbrain. Mutations in ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS), an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of corticospinal and somatosensory tracts to cross the medullary midline.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.