Thermo Fisher Scientific Furin Recombinant Rabbit Monoclonal Antibody (1C3)
Thermo Fisher Scientific의 Furin recombinant rabbit monoclonal antibody (Clone 1C3)는 인간 Furin 단백질을 인식하는 고특이적 항체로, Western blot 및 IHC(P) 응용에 적합합니다. HEK293 세포에서 발현되었으며, 높은 순도와 안정성으로 연구용에 최적화되어 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:5,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1C3 |
| Immunogen | A synthesized peptide derived from human Furin (UniProt ID: P09958-1, antigen range: 230–330) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898255 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
Furin is a membrane-associated, calcium-dependent serine protease belonging to the subtilisin-like prohormone convertase (PC) family. These enzymes cleave prohormones, neuropeptide precursors, and various cellular, viral, and bacterial proteins transported via the constitutive secretory pathway.
Furin shares structural similarities with other PC family members, including:
- ~10 kDa amino-terminal proregion
- ~55 kDa conserved subtilisin-like catalytic domain
- Variable carboxyl-terminal domain
Furin becomes catalytically active after proregion cleavage within the appropriate compartment and is the only PC known to possess a transmembrane domain. It cleaves target proteins at the carboxyl-terminus of the consensus sequence RX(K/R)R. The acidic peptide sequence C771PSDSEEDEG780 localizes furin to the trans-Golgi network, and phosphorylation of serine residues modulates intracellular routing. The Y759KGL762 tetrapeptide sequence directs internalization from the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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