Thermo Fisher Scientific Pan-cadherin Recombinant Rabbit Monoclonal Antibody (23GB5050)

Applications and Tested Dilution

Product Specifications

Target Information

Pan Cadherin (including CDH1, CDH2, CDH3, CDH4) proteins belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion.
Cadherins play a crucial role in morphogenetic movements during development and regulate cell surface adhesion through homotypic interactions with the same cadherin species.

N-cadherin’s function depends on its association with the actin cytoskeleton, mediated through interactions between its C-terminal region and cytoplasmic catenin proteins.
The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.

This gene encodes a classical cadherin from the cadherin superfamily. The protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail.
It functions during gastrulation and is essential for establishing left-right asymmetry. At certain central nervous system synapses, presynaptic-to-postsynaptic adhesion is partly mediated by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.