Thermo Fisher Scientific TMEM66 Polyclonal Antibody
TMEM66 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 동결 조직면 IHC에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체로, 인간·마우스·랫트 반응성. 연구용으로 Ca2+ 조절 관련 단백질 Saraf 분석에 적합.
- 카탈로그번호
- ACC-067-xxxxx (3개 옵션)
- 판매단위
- pk
카탈로그
3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TMEM66 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | (C)ELGLSKLKESGKHQS, corresponding to amino acid residues 141–155 of rat SARAF, Intracellular, lumen |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.85 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g for 5 min).
Target Information
Saraf encodes a protein that negatively regulates store-operated Ca(2+) entry (SOCE), protecting cells from Ca(2+) overload.
Upon cytosolic Ca(2+) elevation after ER Ca(2+) refilling, it promotes slow inactivation of STIM1/2-dependent SOCE activity, possibly by facilitating STIM de-oligomerization to turn off ORAI channels when ER Ca(2+) levels are sufficient, thus preventing excessive Ca(2+) influx.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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