Thermo Fisher Scientific SMAD4/DPC4 (Pancreatic Adenocarcinoma Marker/Tumor Suppressor) Recombinant Rabbit Monoclonal Antibody (SMAD/7906R)
인간 SMAD4 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, 췌장 선암종 마커 및 종양 억제 단백질 연구에 적합. IHC(P)에서 1–2 µg/mL 농도로 사용 가능. 핵 및 세포질 위치 확인용 양성 대조로 활용. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SMAD/7906R |
| Immunogen | Recombinant fragment (around aa400–552) of human SMAD4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human pancreatic ductal adenocarcinoma
- Cellular Location: Nucleus and cytoplasm. Cytoplasmic in absence of ligand; migrates to nucleus when complexed with R-SMAD.
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. Also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 and C-terminal MH2 domains involved in DNA binding and protein interactions.
Binding of TGF-beta or BMP ligands to their receptors leads to phosphorylation of Smad 1, 2, 3, 5, and 8 (R-Smad), which heterotrimerize with Smad4 (co-Smad) and translocate to the nucleus.
Inhibitory Smads (Smad6, Smad7) interact with activated R-Smads to attenuate signaling.
Smad4 functions as a tumor suppressor by transcriptionally regulating target genes such as Cyclin D1 (downregulation) and collagen (upregulation), thereby inhibiting cell proliferation.
Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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