Thermo Fisher Scientific CD81 Monoclonal Antibody (1D6)
CD81 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 1D6). Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. Human, Chimpanzee, Goat, Sheep에 반응하며, 단백질 A로 정제된 저엔도톡신, 무보존제 액상 포맷.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | 1:10 |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chimpanzee, Goat, Human, Sheep |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D6 |
| Immunogen | OCI-LY8 cells aggregated by 5A6 (another CD81 antibody) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2076383 |
Additional conjugate formats available:
- FITC conjugate (Cat. MA1-81261)
- Custom conjugation available upon request
Product Specific Information
- Low-endotoxin, preservative-free formulation (Endotoxin level <0.01 EU/µg).
- For FACS analysis: use 10 µL of the recommended dilution to label 1×10⁶ cells in 100 µL.
- Mouse anti-Human CD81 antibody, clone 1D6, recognizes CD81 (TAPA-1), a 26 kDa cell surface antigen and tetraspanin family member.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a tetraspanin family member expressed on most nucleated cells, especially germinal center B cells. It forms complexes with other tetraspanins, integrins, coreceptors, and MHC molecules, influencing adhesion, morphology, activation, and differentiation of immune cells.
CD81 also:
- Promotes muscle cell fusion and myotube maintenance
- Acts as a receptor for hepatitis C virus envelope protein E2
- Associates with CD19, CD21, and integrins on the cell membrane
- Is localized in a tumor-suppressor gene region and is a malignancy candidate gene
Antibodies to CD81 exhibit anti-proliferative effects on various lymphoid cell lines, particularly large cell lymphomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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