Thermo Fisher Scientific CD45 Monoclonal Antibody (1.11.32), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: Neat
• Publications: View 6 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: -
• Publications: View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• Request custom conjugation

Product Specific Information

• Reconstitute with 1 mL of distilled water.
• After reconstitution, store undiluted at 4°C in the dark.
• For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
• Mouse anti-Sheep CD45 antibody (clone 1.11.32) recognizes ovine CD45 (Leukocyte Common Antigen), expressed on all ovine lymphocytes, macrophages, and granulocytes.

Target Information

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase expressed on all nucleated hematopoietic cells, comprising about 10% of lymphocyte surface proteins.
It is absent on non-hematopoietic cell lines and tissues.
CD45 plays a crucial role in lymphocyte development and antigen signaling by regulating Src-family kinases.
Multiple isoforms arise from alternative splicing, differing in extracellular domains but sharing identical transmembrane and cytoplasmic regions.
It regulates T- and B-cell receptor signaling and JAK kinase activity, influencing cytokine signaling, apoptosis, and integrin-mediated signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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