Thermo Fisher Scientific c-Met Polyclonal Antibody
Human c-Met 단백질을 인식하는 goat polyclonal antibody로, WB, IHC, Flow, Neutralization 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 암 연구 및 신호전달 경로 분석에 유용.
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Thermo Fisher Scientific c-Met Polyclonal Antibody
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.2 µg/mL |
| Immunohistochemistry (IHC) | 5–15 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Neutralization (Neu) | 0.5–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Purified recombinant human hepatocyte growth factor receptor extracellular domain expressed in mouse NSO cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1957467 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions lead to activation of signaling cascades including RAS–ERK, PI3 kinase–AKT, and PLCγ–PKC pathways.
MET plays a role in embryonic development including gastrulation, muscle and neuron development, angiogenesis, and kidney formation. In adults, it is involved in wound healing, organ regeneration, and tissue remodeling.
MET has been linked to cancers including gastric, renal, and breast, making it a target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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